Endometrial cancer type 1 and 2.

endometrial cancer type 1 and 2

Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas. This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian tumors.

Tumor markers in endometrial cancer

Materials and method. The study group included 50 patients from the County Emergency Hospital of Galaţi diagnosed with different histological types of ovarian tumors of the surface epithelium during the period The cases were reviewed in order to highlight the presence of endometriosis and the different histopathological changes.

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The average age of patients in the group with endometriosis associated with ovarian tumors was From the seven cases of tumors associated with endometriosis, two presented areas with atypia, considered premalignant lesions. Based on data obtained, we can conclude that endometriosis with atypia can be a precursor to the occurrence of type I ovarian carcinomas.

Tumor markers in endometrial cancer

Keywords endometriosis, ovarian cancer, atypical endometriosis, premalignant lesion Rezumat Introducere. Mai multe studii anterioare au identificat o asociere între endometrioză şi dezvoltarea carcinoamelor ovariene. Acest studiu urmăreşte prevalenţa endometriozei şi caracteristicile histologice în tumorile ovariene. Materiale şi metodă.

Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale

În lotul de studiu au fost incluse 50 de paciente diagnosticate cu diferite tipuri histologice de tumori ovariene ale epiteliului de suprafaţă în perioada la Spitalul Judeţean de Urgenţă din Galaţi. Cazurile au fost reanalizate în vederea evidenţierii prezenţei endometriozei, precum şi a diferitelor modificări histopatologice ale acestora. Vârsta medie a pacientelor a fost 59,4±11,35 ani în lotul pacientelor care au prezentat endometrioză asociată şi 59,5±13,4 ani în cancer de col uterin la adolescenti pacientelor care au prezentat doar tumori ovariene.

Din cele şapte cazuri de endometrioză, în două cazuri au fost evidenţiate zone cu atipii, endometrial cancer type 1 and 2 leziuni premaligne.

Cancer endometrial

Identificarea endometriozei cu atipii la cele două cazuri — unul diagnosticat cu carcinom cu celule clare, iar celălalt cu carcinom endometrial, ambele incluse în tipul I de cancer ovarian — demonstrează faptul că endometrioza cu atipii poate fi un precursor în endometrial cancer type 1 and 2 carcinoamelor ovariene de tip I. Endometriosis is a gynecological condition, being characterized from a histopathological point of view by the presence of glandular structures at the level of the endometrium and stroma in ectopic locations, such as ovary, pelvis, bladder, Fallopian tube, ovary representing the most common location 4,5.

The literature comprises multiple studies highlighting the link between the presence of endometriosis and its malignant transformation in the ovary, although other studies have not identified associations between these two 6,7. It is estimated that the risk of endometrial cancer type 1 and 2 transformation of endometriosis is comprised between 0. Endometriosis with atypia is described as a preneoplastic endometrial cancer type 1 and 2 and is considered an intermediate pathway for the development of ovarian carcinoma 3.

InSampson described for the first time the implications of endometriosis in neoplastic lesions by establishing several important criteria: the presence of endometriosis and the tumor in the same ovary, a similar histological pattern, the exclusion of the presence of tumor metastasis from other locations 8.

InScott added one more criterion: highlighting the continuity between the benign and the malignant epithelium 9.

HISTOPATHOLOGICAL DIAGNOSIS CRITERIA IN ENDOMETRIAL HYPERPLASIA

Atypia from endometriosis was proposed as a preneoplastic lesion between endometriosis and ovarian cancer, as it refers to two major histological changes: cytological atypia and architectural atypia known as hyperplasia Cytological atypia is highlighted in the epithelium of an endometrial cyst, while the hyperplasia resembles to the hyperplasia present in the endometrium simple or complex with or without atypia Materials and method The study comprises patients of the Emergency County Hospital of Galaţi diagnosed with ovarian carcinoma during the period January — December The histopathological results were analyzed retrospectively to identify the presence of endometriosis.

A number of diagnosed cases and ovarian endometrial cancer type 1 and 2 were analyzed in order to identify the presence or absence of endometriosis, as well as the relationship between these two, endometrial cancer type 1 and 2 on the criteria listed before.

cancer colorectal complication

In this study, we included and evaluated a number of 50 patients diagnosed with epithelial ovarian carcinomas, but also with borderline ovarian tumors. The present study aims to identify the presence of endometriosis outbreaks with or without cytological or architectural atypia hyperplasia.

Incidence of endometriosis and atypical endometriosis in epithelial ovarian tumors

Each case was evaluated from a histopathological point of view. The number of paraffin blocks varied depending on the surgical pieces, being between 4 and 12 blocks, the slides resulting from the section of these blocks being processed and colored using the classic hematoxylin and eosin coloration.

endometrial cancer type 1 and 2

The following clinical and pathological data of the patients were taken into account: age, menopausal status, tumor histological type, tumor grading at the time of ovarian diagnosis.

The staging was made retrospectively according to the system of the International Federation of Gynecology and Obstetrics FIGO after cases have been analyzed. The histological classification of ovarian carcinomas was based on the classification WHO of ovarian tumors.

Results The histopathological evaluation performed on the group of 50 patients during the period has the following results: 45 cases were diagnosed with malignant tumors, 5 cases being borderline tumors. Figure 1. Figure 2. From the seven patients with endometriosis, None of the cases of borderline mucinous tumors, mucinous carcinoma, and undifferentiated carcinoma presented associated endometriosis outbreaks Table 1.

Table 1.

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The presence of endometriosis in the appendages was Two of the seven cases in which the areas of endometriosis were visualized presented also endometriosis with atypia one case of complex hyperplasia, and the other with cytological atypia in the wall of an endometrial cyst. In our study, the average age at the moment of diagnosis was

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