Colorectal cancer in the young.

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Accepted Apr Copyright © The Authors. This is an open access article under the colorectal cancer in the young of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.

TR Microsatellite instability MSI Instabilitatea microsatelitară MSI este o afecțiune care apare pe ADN-ul celulelor specifice cum ar fi celulele canceroase unde numărul de microsateliți repetiții scurte ale secvențelor ADN din aceste celule este diferit de repetările care au existat în ADN atunci când a fost moștenit. Această instabilitate este cauzată de funcționarea defectuoasă a mecanismului de reparare mecanismul de reparare a erorilor de replicare ADN, MMR a erorilor în timpul replicării ADN-ului. Microsateliții, sau tandemuri scurte repetitive, sunt secvențe repetitive de ADN cu funcție necunoscută în genom, care apar stabile pe durata existenței unui individ. Cu toate acestea, fluctuațiile în lungimea microsatelitului, numită instabilitate, pot însemna că genele de reparare a erorilor de replicare nu funcționează corect. Repararea defectuoasă a erorilor de replicare este cauzată în cea mai mare parte de o anomalie de metilare a genei de reparare a erorilor de replicare MLH1, care este în primul rând un eveniment sporadic neereditar.

Abstract Given the abundance of misreporting about diet and cancer in the media and online, cancer survivors are at risk of misinformation. The aim of this study was to explore cancer survivors' beliefs about diet quality and cancer, the impact on their behaviour and sources of information.

colorectal cancer in the young

Interviews were analysed using Thematic Analysis. Emergent themes highlighted that participants were aware of diet affecting risk for the development of cancer, but were less clear about its role in recurrence. Nonetheless, their cancer diagnosis appeared to be a prompt for dietary change; predominantly to promote general health.

Participants reported that they had not generally received professional advice colorectal cancer in the young diet and were keen to know more, but were often unsure about information from other sources.

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The views of our participants suggest cancer survivors would welcome guidance from health professionals. Keywords: beliefs, cancer survivorship, diet, information, knowledge, media 1.

Microsatellite instability (MSI)

The mechanisms linking dietary fat intake with cancer outcomes are not well understood but are thought to be related to sex hormones such as oestrogen. On the other hand, intervention studies suggest that diet may influence outcomes indirectly via its role in energy balance Chlebowski et al.

Many organisations have lifestyle guidelines for cancer prevention Kushi et al.

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Insufficient professional advice coupled with a desire for information may lead some cancer survivors to seek out information about diet themselves. However, when searching in popular media or online, cancer survivors are likely to encounter a wealth of information, not all of which will be reliable and accurate.

There is an abundance of media misreporting of the dietary factors that are linked to cancer risk Goldacre, that could be misleading to patients, particularly if they believe the sources to be trustworthy.

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However, these studies did not explore survivors' use of the media for information about diet and were conducted some time ago. Determining cancer survivors' sources of information about diet and cancer will help understand why they hold particular beliefs about these factors.

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Qualitative research enables us to capture a range of views and to explore why those views are held. Methods 2. This also meant we would be representing a wide range of views, applicable to the wider survivorship population as opposed to focusing on a more specific group.

Interviews were chosen over focus groups as we were interested in hearing about patients' individual beliefs and experiences, rather than determining a group consensus. Telephone interviews also encouraged individuals to take part that might have otherwise been put off by a lack of flexibility around time e.

ABC of Colorectal Cancer - Annie Young

A qualitative methodology was chosen because we were not seeking to test a hypothesis, but rather to obtain a rich source of information to better understand the rationale behind dietary beliefs and changes in this population Holliday, During this telephone call, information was given about the study with an opportunity to ask questions.

We aimed to recruit until it was felt that saturation had been reached.

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Interviews lasted approximately 1 hr, and were recorded and transcribed verbatim. A topic guide Figure  1 was developed by HC, KW and RB to guide the interviews and consisted of a series of open questions covering beliefs about the relationship between diet and cancer, sources of information and changes to diet following cancer diagnosis.

This was part of a broader interview that also covered participants' views about other lifestyle factors and cancer.

  1. Николь закрыла глаза, пытаясь припомнить свое детство.

  2. ABC of Colorectal Cancer - Annie Young
  3. Microsatellite Instability (MSI)
  4. Dezintoxicarea si tratamentul cu uleiuri vegetale
  5. Que son papilomas en la piel

Interviewers were trained to have minimal verbal input and prompt only when appropriate Oppenheim, The topic guide was piloted with two participants whose data were included because no substantial changes were required.

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