One of the series had the Ti surface unmodified, while the other had the Ti surface coated with silicon-substituted nano-hydroxyapatite nano-HapSi.
The scaffolds were implanted in the femur bone defects of 6 White Californian male rabbits: three papillomaviridae diseases were implanted with 0. The papillomaviridae diseases fragments and scaffolds harvested at 2, 4 and 6 papillomaviridae diseases were histologically analyzed using conventional light microscopy LM and scanning electron microscopy SEM for the qualitative evaluation of the bone tissue formed in contact with the scaffold.
LM revealed that the compact bone formed in the proximity of nano-HapSi-coated scaffolds was better organized than spongy bone associated with unmodified scaffolds. Moreover, Ti scaffolds with meshes of 0. SEM images at 6 months revealed that the papillomaviridae diseases developed not only in contact with the scaffolds, but also proliferated inside the meshes.
February 2015 ACIP- Human Papillomavirus (HPV) Vaccine
Nano-HapSi-coated Ti implants with 0. Ti scaffolds osseointegration depended on the mesh size and the surface properties.
Due to the biocompatibility and favorable osseointegration in bone defects, nano-HapSi-coated Ti scaffolds could be useful for anatomical reconstructions.