Research tendencies in transplant biology field, presently, point to immunologic evaluation, rapid andaccurate virological diagnostic, and the response to immunosuppression.
Mustafa TurkyilmazogluDepartment of Mathematics, University of Hacettepe, Turkey Research interests: Fluid mechanics, Hydrodynamic stability theory, Rotating-disk flow, High-Reynolds number flows, Triple-deck asymptotic theory of compressible viscous flows, Numerical simulation.
Transplant studies around the world, are focused on a deeper understanding of the genetic mechanisms involved in facilitating or tempering graft rejection or post-transplant viral infections, as well as on molecular mechanisms, cancer treatment genetic engineering sustains certain immunosuppressive therapy response particularities. In this context, the objectives of the project were to: Investigate polymorphisms in IL-6, IL, TNFα, IFNγ genes and their receptors, and serum level of these cytokines in transplant recipients Evaluate correlation of the immunogenetic profile with post-transplant rectal cancer prevalence infections Evaluate correlation of the immunogenetic profile with acute rejection episodes frequency Evaluate correlation of the immunogenetic profile with immunosuppressive therapy response Set-up an in vitro model system for validation of the results obtained through genetic analysis Elaborate hypothesis on genetic risk factors involved in post-transplant viral infections and rejection episodes, as well as in immunosuppressive therapy response.
Diagnostic Techniques in Genetics
A wide range of investigations have been performed for detection, diagnosis and monitoring viral infections and graft rejection in liver and renal transplant recipients. The results of the proposed study help to elucidate the role of the cytokine genes in the complex gene network involved in immune response, and especially in organ transplant immunity. Bucsa, B. Tacu, C. Dobrea, E. Kerezsy, I. Ursuleac, I.
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Alexiu, V. Uscatescu, I. Gratiela Tardei, Alexiu I. Bleotu C. Mar 27 [Epub ahead of print] Pathol Biol Paris.
Carmen C. Diaconu; scientific responsible: Dr. Cancer treatment genetic engineering myeloproliferative disorders CMPDs are a heterogeneous group of hematologic malignancies arising from a multipotent hematopoietic stem cell.
The molecular pathogenesis of these disorders has been poorly understood, except for chronic myeloid leukemia CML. The recently identified unique activating mutation in JAK2 kinase that activates the downstream signaling pathways appears to be the key genetic event for most of CMPDs patients. Cancer treatment genetic engineering from JAK2 VF positive and negative MPD patients will be examined for blood cell differentiation in colony assays, response to cytokines and for the JAK2 VF-negative cells will be examined for additional genetic abnormalities.
Patients negative for JAK2 Cancer treatment genetic engineering will be investigated for other genetic abnormalities using molecular genetic methods and modern cytogenetic tests FISH with locus-specific, centromere-specific and chromosome-specific probes. Samples from MPD patients in dynamics will be invaluable for further identification of which genetic or epigenetic events may promote evolution of Polycythemia Vera or Thrombocythemia versus Myelofibrosis and eventually to acute myeloid leukemia.
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The accomplishment of this project would prove essential for implementation of advanced methods of molecular diagnosis in Romania warts skin feet will allow the integration of our research teams in The Frame Programs Of European Union. The interest regarding hematopoietic stem cells increased in last decade due to their potential to supply essential material for advanced therapies like gene therapy, cellular therapy and tissue regeneration.
Hematopoietic stem cell promise for clinical therapy is nevertheless restricted due to reduced availability of traditional virus del papiloma humano complicaciones cell sources: bone marrow and peripheral blood. The umbilical cord blood is used in special in pediatric cases, but his application is rapidly extending to adult patients.
It is considered an excellent stem cell source especially for patients who have un cancer treatment genetic engineering HLA constellation and need an urgent transplant procedure. The project specific aim is to find effective methods for improving clinical results of using umbilical cord blood stem cells in transplant, by obtaining an optimum cell graft.
For that purpose, the establishment of effective methodology, technically relevant, for ex vivo cultivation of these cells, will be done, through manipulation of culture microenvironment by cytokines supplementation. Animal studies will be realized in order to investigate the efficiency of allotransplant clinical protocols using umbilical cord blood stem cells, for initiate cell therapy procedures in patients with malignant disorders, hepatic failure and inborn congenital disorders.
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The project will conduct to organization of a bank facility for umbilical cord blood according with international quality standards and ethical rules. Cellular therapy in liver disease represents a new, promising cancer treatment genetic engineering approach. The adult stem cells from mobilized peripheral blood may represent a considerable advantage in their use for the therapy of hepatic lesions because could be harvested from live donors by a minimally invasive technique.
The specific activities are: differentiation of hematopoietic stem cells through hepatic-cell-like suitable to participate in liver regeneration after transplant; development of the animal cancer treatment genetic engineering with hepatic failure for in vivo assessment of liver regeneration capacity of adult stem cells; implementation of cellular therapy procedure for patients with end stage liver disease.
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The proposed research has the potential to increase the data about liver stem cell biology, representing a new source of data for the future clinical trials.
The cancer treatment genetic engineering involves complex research activities realized in partnership by 5 highly specialized units cancer treatment genetic engineering complementary top domains. Through the tissue engineering methods proposed for intestinal fistula treatment, the project follows to perform some innovative techniques, which involves original pre-testing experiments on animal models.
The matrix includes the culture of autologous mesenchymal stem cell on 3D collagen structure and arterial wall.
The biological product will be characterized histological and tested biochemical, bacteriological. The obtained 3D matrix will be experimental tested on animals.
If favorable results will be obtained on animal models, the possibility for treating also human voluntaries patients will be considered. Taking into account the differences in physiology and susceptibility to antibiotics of biofilm embedded bacteria, the international concerted efforts for finding new methods for the study of microbial adherence and aggregation, as well as new strategies for the diagnosis and therapy of biofilm associated infections are absolutely needed.
The main objective of the project is to promote and disseminate the methodological and scientific information on biofilms and their medical relevance, in the purpose to improve the results of prevention, diagnosis and therapy of biofilm associated infections.
Specific activities: the setting up of the biological material background required for the optimal development of the scientific activities collection of microbial strains isolated from medical biofilms, the investigation of intrinsic and cancer treatment genetic engineering parameters of microbial adherence on cellular substrata and prosthetic devices by using original experimental models for the development of artificial monospecific biofilms; the in cancer treatment genetic engineering assessment of the phenotypic resistance of adhered and biofilm embedded microbial strains to different antimicrobial factors; pilot study for the implementation in clinical laboratory of an optimized method for susceptibility testing and assessment of therapeutic doses for biofilm associated infections; elaboration of guidelines for prevention, diagnosis and therapy of infections with microorganisms adhered to tissues and prosthetic devices.
This project is framed in the thematic area No. The innovative, multinational and multidisciplinary Health Surveillance System in the Polar Area HSSPto the development of which we shall contribute by ours proposed actions will improve the generation standardization, acquirement and analysis of the biomedical data regarding polar zones.
It will also stimulate the experimental progress in the field of biomedical research by multiple applications in the humanitarian, military, space voyages spheres, in the natural and industrial disasters, as well as of other environmental challenges. The international and multidisciplinary collaboration promoted by our proposed actions in the field of the cancer treatment genetic engineering and physiology of viruses as well as of the biomedical applications of the Antarctic organisms, will assure the acquirement of an advanced knowledge in the basic science Biology for the next FP7 protocols.
The project is intended to take advantage of a longlasting collaboration of the project director with outstanding german scientists in the field of psychiatric genetics. The first objective of the project is the extention of the Romanian involvement in international psychiatric genetics projects through cancer treatment genetic engineering the biological molecular cancer treatment genetic engineering to the clinical-biometric cooperation and the setting up of a Romanian psychiatric genetics research group capable to participate in international collaborative projects.
The second objective of the project is cancer treatment genetic engineering informational and technological transfer through the training of Romanian researchers in genetic techniques genome scan, secventiation, identification of new genes and epigenetics [the microarray techniques DMH differential methylation hybridization ; MSPCR Methylation Specific PCR ] in Germany.
The practical use of these methods will occur in a pilot study intended to replicate some candidate genes for bipolar manic-depressive disorder particularly G72 gene and to explore their methylation pattern in a Romanian patient sample partially recruited during the current project.
Department of Cellular and Molecular Pathology
The project considers short research stays of the Romanian researchers in Germany, visits of the German scientists to Romania for short courses, practical training and participation in joint conferences and the effective performance of an exploratory pilot study using Romanian clinical and biological material for testing new psychiatric genetic hypotheses putative involvement of altered methylation patterns of genes associated with bipolar disorder.
Moreover, the collection of DNA from a Romanian sample of bipolar patients and normal controls is intended; this sample will be integrated in a large European sample for genetic study of bipolar disorder and will serve to replicating genes identified in other European samples.
Потом светляки повернули направо и двинулись вдоль опушки леса, казавшегося мрачным и непривлекательным. Время от времени Ричард и Николь слышали странные громкие звуки, доносившиеся из чащи. Раз Ричард остановился и направился к месту, где начиналась густая поросль.
Likewise, the project is compatible with the thematic field 1.