Familial cancer author instructions,

Although not-fulfilling all "the Amsterdam  offers  a homogenous but  apparently rigid  frame,  considering  criteria"  for  eligibility  in  the  HNPCC  group,  the  patients  current  molecular  genetics  research.

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Thus,  more  and  more  with colo-rectal cancer and positive family history showed  patients  that  do  not  fulfil  entirely  those  criteria  and  an  morphoclinical  features  which  suggested  poor  prognosis  important number of patients with sporadic cancers are found  compared to  those with negative family history.

A  comparative  analysis  of the  morphoclinical  Key  words  features  in  non-polyposis  colo-rectal  cancer  patients  with  Hereditary  colo-rectal  cancer  -  Amsterdam  Criteria  - positive  family  histories  which  fulfil  entirely  or  partially  prognosis  "the  Amsterdam  criteria"  versus  the  patients  with  sporadic  non-polyposis  colorectal  cancers.

Patients  and  methods. We  performed  a  retrospective  a n a l y s i s  on  c o l o - r e c t a l  c a n c e r  p a t i e n t s  o p e r a t e d  consecutively  by the  same  surgical  team. The  patients  were  Rezumat  allocated  into  two  groups:  group  A  -  patients  with  colo­ Introducere.

The  cases  respecte  "criteriile  Amsterdam"  care  asigură  un  cadru  with familial polyposis  and those with uncertain family history  omogen  dar  aparent  rigid  în  lumina  noilor  cercetări  de  were  excluded. We  analyzed  comparatively  the  familial cancer author instructions genetică  moleculară. Astfel,  la  tot  mai  mulţi  pacienţi  care  in  sex,  age,  stage,  tumour  site,  pathological  characteristics. A  number  of    colo-rectal  cancer  patients  Scopul  cercetării.

Analiza  comparativă  a  particularită­ underwent  surgery  between    and  their  medical  ţilor  morfo-clinice  la  pacienţi  cu  cancere  familial cancer author instructions non- records  were  assessed retrospectively.

The group A contained  polipoase  cu  familial cancer author instructions heredo-colaterale  familial cancer author instructions şi  care  30  patients  with  colo-rectal  cancer  and  positive  family  întrunesc  parţial  sau  total  "criteriile  Amsterdam"  faţă  de  history  and  group  B  consisted  of    patients  with  colo­ pacienţii  cu  cancere  colo-rectale  non-polipoase  sporadice.

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We  noted  Material  şi  metodă. Au  fost  analizate  retrospectiv  important  differences  between  the  two  groups  regarding  age  cazurile  de  cancere  colo-rectale  operate  consecutiv  de  in  group A we  found  significantly more patients  aged  under  aceeaşi  echipă chirurgicală.

We aim to present cases series confirmed with polythelia and introduce a mini-review of the PubMed literature. Cases series: Eight adult patients confirmed with sporadic unilateral polythelia on the milk line were included. Left right ratio was three to five.

Au  fost  Vol. Mircca  Cazacu  antecedente  heredo-colaterale  incerte.

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Grupul A a cuprins 30  family  history  were  excluded. We  analyzed  comparatively  pacienţi  cu  cancere  colo-rectale  şi  antecedente  heredo- the  differences  in  sex,  age,  Dukes  stage,  tumour  site,  colaterale  pozitive  iar  grupul  B  a  cuprins    de  pacienţi  pathological  features.

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Deosebiri  importante  au  fost  decelate  între  cele  significant. Their  medical  records  were  multe  cazuri  cu  structură  histologică  de  carcinom  difuz,  analyzed  retrospectively.

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The  group  A consisted of 30  patients with  positive  family  Concluzii. Deşi  pacienţii  noştri  cu  cancere  colo-rectale  history  and  group  B  contained    patients  with  negative  şi  antecedente  familiale  pozitive  nu  întrunesc  toate  family  history.

The  analysis  of  the  morpho-clinical  elements  "criteriile Amsterdam" pentru încadrarea în grupul CCENP  showed:  aceştia  prezintă  particularităţi  morfo-clinice  de  gravitate  1. Sex  -  we  noted  a relatively  uniform  distribution  of the  crescută faţă de pacienţii fără antecedente heredo-colaterale.

Age  -  the  median  age  was  Staging  -  considering  the  distribution  of the  cases  in  entirely  "the  Amsterdam  criteria".

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The relationship with the "Amsterdam Criteria":  there  rectal  cancer  in  order  to  detect  the  differences  between  was  no  patient in  group  A that fulfilled  all  "The  Amsterdam  patients  with  positive  malignant  family  history  and  those  Criteria":  5  patients  fulfilled  1  criteria,  9  patients  fulfilled  2  with  no  such  history.

Discussions  Material and methods  The  scientific  approach  of  the  hereditary  colo-rectal  We  analyzed  retrospectively  cases  of colo-rectal  cancer  cancers  has  changed  very  much  after the  discovery  of tumor  familial cancer author instructions on  by  the  same  surgical  team.

Polythelia: Cases series and mini-review of the literature

The  patients  were  microsatellite  instability. Hereditary non-polyposis colo-rectal cancer between dogma and reality There are certain conditions which need to be fulfilled We consider that by confronting this situation, we can in order to permit the allocation of a patient in the HNPCC apply one of the new clinical subdivisions of colorectal group conditions defined in as "The Amsterdam cancer which allows the allocation in one of the 5 groups: Criteria".

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The presence of familial cancer author instructions cancers pathologically 2 HNPCC suspect - the cases that do not comply with all confirmed in at least three members of the family, one of the standard criteria; them being a first degree relative to the schistosomiasis rash. Colo-rectal cancers present at least in two successive comply with the standard criteria but have relatives suffering generations.

At least one of the family members diagnosed when 4 juvenile types - cases that fulfil only one criteria and aged under Although none of gene mutation This aspect has important - the estimation of individual risk, currently done by consequences regarding the indication of genetic testing of means of genetic testing, with all its social and economical all family members and the eventual costs of screening consequences, evaluation of certain risk groups 5. Thus we use on a Thus, taking as genetic criteria the presence of mismatch- large scale family history investigation and also laboratory repair-gene mutation, the situations which suggest the tests and we hope the future will bring us new techniques presence of a hereditary colorectal cancer are: such as the detection of human leucocyte antigens as genetic - the presence of colorectal cancer in at least 3 family markers in colo-rectal carcinoma Among the 30 cases operated by us follow-up.

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References Facing this diversity we compared the main morpho- 1. Vincent T. DcVita Jr.

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The familial cancer author instructions were Hereditary colorectal familial cancer author instructions Gut ;

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