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Although not-fulfilling all "the Amsterdam  offers  a homogenous but  apparently rigid  frame,  considering  criteria"  for  eligibility  in  the  HNPCC  group,  the  patients  current  molecular  genetics  research.

Thus,  more  and  more  with colo-rectal cancer and positive family history showed  patients  that  cancer genetic percentage not  fulfil  entirely  those  criteria  and  an  morphoclinical  features  which  suggested  poor  prognosis  important number of patients with sporadic cancers are found  compared to  those with negative family history.

A  comparative  cancer genetic percentage of the  morphoclinical  Key  words  features  in  non-polyposis  colo-rectal  cancer  patients  with  Hereditary  colo-rectal  cancer  -  Amsterdam  Criteria  - positive  family  histories  which  fulfil  entirely  or  partially  prognosis  "the  Amsterdam  criteria"  versus  the  patients  with  sporadic  non-polyposis  colorectal  cancers.

Patients  and  methods. We  performed  a  retrospective  a n a l y s i s  on  c o l o - r e c t a l  c a n cancer genetic percentage e r  p a t i e n t s  o p e r a t e d  consecutively  by the  same  surgical  team.

Figure IV-2 Relation between additional lung-cancer frequency and cumulative radiation exposure in three groups of Czechoslovakian uranium miners by time course of exposure accumulation see text. Source: Kunz et al. An earlier report 28 of follow-up through is the only report on the cohort of Cancer genetic percentage uranium miners that provided observed and expected mortality rates per 10,

The  patients  were  Rezumat  allocated  into  two  groups:  group  A  -  patients  with  colo­ Introducere. The  cases  respecte  "criteriile  Amsterdam"  care  asigură  un  cadru  with familial polyposis  and those with uncertain family history  omogen  dar  aparent  rigid  în  lumina  cancer genetic percentage cercetări  de  were  excluded.

We  analyzed  comparatively  the  differences  genetică  moleculară. Astfel,  la  tot  mai  mulţi  pacienţi  care  in  sex,  age,  stage,  tumour  site,  pathological  characteristics. A  number  of    colo-rectal  cancer  patients  Scopul  cercetării.

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cancer genetic percentage Analiza  comparativă  a  particularită­ underwent  surgery  between    and  their  medical  ţilor  morfo-clinice  la  pacienţi  cu  cancere  colo-rectale  non- records  were  assessed retrospectively.

The group A contained  polipoase  cu  antecedente  heredo-colaterale  pozitive  şi  care  30  patients  with  colo-rectal  cancer  and  positive  family  întrunesc  parţial  sau  total  "criteriile  Amsterdam"  faţă  de  history  and  group  B  consisted  of    patients  with  colo­ pacienţii  cu  cancere  colo-rectale  non-polipoase  sporadice.

We  noted  Material  şi  metodă. Au  fost  analizate  retrospectiv  important  differences  between  the  two  groups  regarding  age  cazurile  de  cancere  colo-rectale  operate  consecutiv  de  in  group A we  found  significantly more patients  aged  under  aceeaşi  echipă chirurgicală.

Au  fost  Vol. Mircca  Cazacu  antecedente  heredo-colaterale  incerte.

Introduction

Grupul A a cuprins 30  family  history  were  excluded. We  analyzed  comparatively  pacienţi  cu  cancere  colo-rectale  şi  antecedente  heredo- the  differences  in  sex,  age,  Dukes  stage,  tumour  site,  colaterale  pozitive  iar  grupul  B  a  cuprins    de  pacienţi  pathological  cancer genetic percentage.

Deosebiri  importante  au  fost  decelate  între  cele  significant. Their  medical  records  were  multe  cazuri  cu  structură  histologică  de  carcinom  difuz,  analyzed  retrospectively.

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The  group  A consisted of 30  patients with  positive  family  Concluzii. Deşi  pacienţii  noştri  cu  cancere  colo-rectale  history  and  group  B  contained    patients  with  negative  şi  antecedente  familiale  pozitive  nu  întrunesc  toate  family  history.

The  analysis  of  the  morpho-clinical  elements  "criteriile Amsterdam" pentru încadrarea în grupul CCENP  showed:  aceştia  prezintă  particularităţi  morfo-clinice  de  cancer genetic percentage 1. Sex  -  we  noted  a relatively  uniform  distribution  of the  crescută faţă de pacienţii fără antecedente heredo-colaterale. Age  -  the  median  age  was  Staging  -  considering  the  distribution  cancer genetic percentage cases  in  entirely  "the  Amsterdam  criteria".

The relationship with the "Amsterdam Criteria":  there  rectal  cancer  in  order  to  detect  the  differences  between  was  no  patient in  group  A that fulfilled  all  "The  Amsterdam  patients  with  positive  malignant  family  history  and  those  Criteria":  5  cancer genetic percentage fulfilled  1  criteria,  9  patients  fulfilled  2  with  no  such  history.

Discussions  Material and methods  The  scientific  approach  of  the  hereditary  colo-rectal  We  analyzed  retrospectively  cases  of colo-rectal  cancer  cancers  has  changed  very  much  after the  discovery  of tumor  operated  on  by  the  cancerul cerebral plan de ingrijire surgical  team.

The  patients  were  microsatellite  instability. Hereditary non-polyposis colo-rectal cancer between dogma and cancer genetic percentage There are certain conditions which need to be fulfilled We consider that by cancer genetic percentage this situation, we can in order to permit the allocation of a patient in the HNPCC apply one of the new clinical subdivisions of colorectal group conditions defined in as "The Amsterdam cancer which allows the allocation in one of the 5 groups: Criteria".

The presence of colo-rectal cancers pathologically 2 HNPCC suspect - the cases that do not comply with all confirmed in at least three members of the family, one of the standard criteria; them being a first degree relative to the others. Colo-rectal cancers present at least in two successive comply with the standard criteria but have relatives suffering generations.

The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early stage, avoiding expenses of treatment for advanced cancers and extra years of productivity. But screening tests also have disadvantages, so a balanced decision must be made, with the help of clinical randomized trials. In this article I will present the current methods for screening accepted for general population and particular screening reserved for persons at high risk. Although in the first case the benefit is proven, the use of these methods in practice varies largely due to lack of resources and well designed health programs. Beneficiile sunt evidente în anumite cancer genetic percentage prelungirea su­pravieţuieii la cei cu boală curabilă, scăderea morbidităţii, asigurarea pacientului că boala se află în stadiu incipient, evitarea costurilor crescute asociate cu tratamentul for­melor avansate de boală şi creşterea numărului de ani de productivitate.

At least one of the family members diagnosed when 4 juvenile types - cases that fulfil only one criteria and aged under Although none of gene mutation This aspect has important - the estimation of individual risk, currently done by consequences regarding the indication of genetic testing of means of genetic testing, with all its social and economical all family members and the eventual costs of screening consequences, evaluation cancer genetic percentage certain risk groups 5.

Thus we use on a Thus, taking as genetic criteria the presence of mismatch- large scale family history investigation and also laboratory repair-gene mutation, the situations which suggest the tests and we hope the future will bring us new techniques presence of a hereditary colorectal cancer are: such as the detection of human leucocyte antigens as genetic - the presence of colorectal cancer in at least 3 family markers in colo-rectal carcinoma Among the 30 cases operated by us follow-up.

References Facing this diversity we compared the cancer genetic percentage morpho- 1. Vincent T.

Prevenirea cancerului prin intermediul unor programe de screening

DcVita Jr. The differences were Hereditary colorectal ; Gut ; Familial and hereditary cancer genetic percentage in colorectal cancer: a new 4. Baba S.

HBV infection of a wide variety of cell types has been reported, but productive infection and pathology appear to be limited to the liver. Among the many cell types found in the liver, HBV infects the hepatocyte, the major parenchymal cell. Following infection, virus is shed from hepatocytes into the bloodstream, so that every hepatocyte may become infected. During the peak of an infection, titers of virus in the blood may reach per cubic centimeter. Infection of hepatocytes is not typically cytopathic, and the liver pathology results from the cancer genetic percentage response to the infected cells.

Hereditary nonpolyposis colorectal cancer: an update. Dis Colon Rectum ; 40 10 Suppl : S Br J Cancer ; 73 Suppl 26 Hereditary nonpolyposis Genetics of cancer genetic percentage cancer.

Non-polyposis and polyposis criteria show extremely low frequency of mismatch-rcpair-gcnc forms of hereditary colorectal cancer. Ned Tijdschr Gcnecskd mutations.

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Am J Hum Genet ; Family history Genetic testing in characteristics, tumor microsatcllitc instability and gcrmlinc hereditary colorectal cancer: indications and procedures. Gastroenterol ; Hum Genet ; Varying features of clinical consequences of predictive molecular testing. Int J early agc-of-onsct "sporadic" and hereditary nonpolyposis colo- Colorectal Dis ;

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