Cancer genetic alteration. Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva

FRECVENŢA MUTAŢIILOR GENEI CDH1 ÎN CANCERUL DIGESTIV.

Department of Ophthalmology, Grigore T.

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E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction.

The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

Tipuri[ modificare modificare sursă ] Un neoplasm poate fi benign, potențial malign sau malign cancer. Sunt circumscrise și localizate, și nu se transformă în cancer. Sunt localizate, nu invadează și nu distrug, dar în timp, se pot transforma într-un cancer.

The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.

Sugestii a familial match Familial disease of Bernese mountain dogs, accounts for up to 25 percent of all tumors in this breed Boala familial de Bernese caini de munte, Conturile de până la 25 la suta din toate tumorile în aceasta rasa Familial hematuria a condition in which blood in the urine runs in certain families of animals is usually implicated in young dogs, while cancer is the usual cause in older dogs. Familial hematurie o afectiune in care sangele, în urină se execută în anumite familii de animale este, de obicei implicat în cazul câinilor tineri, în timp ce cancerul este cauza de obicei la câinii mai mari.

Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half. He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.

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The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses. All other ophthalmological findings were normal.

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Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the cancer genetic alteration and neck showed no signs of tumor invasion of the orbit or the lymph nodes.

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The limbic lesion was removed surgically with cancer la plamani stadiu 4 mm margin of normal tissue and cancer genetic alteration of the adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

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Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.

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