Abstract Aim: to describe two cases of familial papillary thyroid carcinoma.
Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case. Results and discussion: cancer familial syndromes presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule.
After cancer familial syndromes for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease.
Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging.
Factorii de risc ai cancerului colorectal
The biopsy identified a papillary thyroid carcinoma. Case 2: the son of the patient 30 years old without known diseases was invited to be assessed for thyroid disease. Ultrasound examination discovered a large nodule with microcalcifications. Microscopic examination done after total thyroidectomy revealed a cancer familial syndromes morular variant of papillary thyroid carcinoma, a variant that is known to be associated with FAP. Radioiodine ablation was made followed by suppressive thyroxine treatment.
In the second case adenomatous polyposis was not found yet.
This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy. In this presentation, we mention the histological cancer familial syndromes of pancreatic cancer, the importance of systemic therapy for operable cases pre- and post-surgeryand of chemotherapy for advanced and metastatic cancer. New therapeutic agents have been introduced, that appear to give new hope for a more efficient treatment. Acest cancer are o mortalitate ridicată, iar supravieţuirea globală este de asemenea scăzută.
In our knowledge these are the first cases of familial thyroid papillary carcinomas in our setting. Familial history allowed an earlier diagnosis and cancer familial syndromes good management of the disease in the second case. Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP and in those with a FAP proband in the family.
Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption. Evidence is mounting that detecting this risk factors is a eficient way of selecting persons at high risk for colon cancer, that should undergo the screening mesures.
Nosé V. Endocr Pathol.
Browsing Háskóli Íslands by Author "Jinga, Viorel"
Modern Pathology ; SS Cavaco BM. Endocrine-Related Cancer ; Richards ML. Thyroid ; Nilbert M, Kristoffersson U, Ericsson M, et al: Broad phenotypic spectrum cancer familial syndromes familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age BMC Med Genet. Orphanet J Rare Dis ; 7.
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FAMILIAL SYNDROMIC PAPILLARY THYROID CARCINOMA - REPORT OF TWO CASES
Fam Cancer. Cancer familial syndromes S, Hong SW, Shin SJ,et al: Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of the literature. Endocr J.
Она ощутила руки, обхватившие ее за плечи. И только через несколько секунд Николь поняла, что спала. Ричард с тревогой глядел на. Прежде чем Николь смогла заговорить, в спальню вошла Элли в халате.
Am J Otolaryngol. Cetta F. Acta Cytol. Kurihara K, Shimizu S, Chong J, et al: Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma.
Jpn J Cancer Res. Ito Y, Miyauchi A, Ishikawa H, et al: Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients. Mc Donald TJ. Journal of Oncology. Nasr MR. Modern Pathology.
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