Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users.
HUMAN PAPILLOMA VIRUS GENOTYPING IN FRESH HEAD AND NECK TUMORS - OUR FIRST EXPERIENCE
Conclusions: The genotyping method was validated according to kit instructions. To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples.
In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papillomavirus HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type protein RBP involved in the regulation of proliferation and cell death. Materials and method.
Ferlay J, Soerjomataram I et al. Comprehensive control of human papillomavirus infections and related diseases. Venuti A, Paolini F.
Infecţia cu HPV (human papilloma virus) la bărbaţi
Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Ursu RG, Danciu M et al. Virol J.
Human papillomavirus prevalence in invasive laryngeal cancer in the United States. Shanesmith R, Allen RA et al.
Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cell carcinomas. HPV genotype distribution in oral and oropharyngeal squamous cell carcinoma using seven in vitro amplification assays.
This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions. The immunization rates for Human papillomavirus are generally lower than for other types of vaccines, and further implementation of appropriate strategies is still needed.
Garnaes Squamous papilloma virus, Kiss K et al. A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, the largest registry-based study to date. Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain Low human papillomavirus prevalence squamous papilloma virus head and neck cancer: results from two large case-control studies in high-incidence regions.
Westra WH. Heiduschka G, Grah A et al. Masterson L, Moualed D et al.
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systema-tic review and meta-analysis of current clinical trials.